(Geneva, Switzerland) An advisory group of experts taking part in a meeting organized by the WHO Global Influenza Programme between 25-28 September 2023 analyzed influenza virus surveillance data generated by the WHO Global Influenza Surveillance and Response System (GISRS), and issued on 29 September 2023, recommendations on the composition of the influenza vaccines for the following influenza season.
These recommendations are used by the national vaccine regulatory agencies and the pharmaceutical companies to develop, produce and license influenza vaccines.
After mixed efforts in 2020, followed by a massive explosion of Omicron data generated by late 2021 from 215 countries and territories, the number of unique submitting countries, and hence, representativeness of global surveillance, today remains at early 2021 levels, and well above 2020 levels.
While the US, UK, and Germany contributed an outsized share in 2022, it is worth pointing out that increasing representation of diverse regions over time, and the timeliness of submissions are far more critical to ensure new variants are detected in real-time. The recent timely discovery of BA.2.86 and EG.5.1 are examples of continued effectiveness so far.
A clade of highly pathogenic avian influenza (HPAI) viruses, originating from poultry but subsequently identified in migratory birds, is severely impacting wild bird populations, including endangered bird species. Over 100 million birds have been killed across the globe, making this the largest outbreak in poultry in history. The current H5N1 clade 22.214.171.124b is also affecting South America where several countries have recorded their first ever cases.
Events with mammal-to-mammal transmission have been reported, including in farmed mink and in marine mammals. Although HPAI H5N1 can cause serious disease in humans, no known human-to-human spread has been identified. GISAID is closely working with its partners to help facilitate the timely sharing of the latest genomic data.
Yogyakarta, 20-21 June. Under the motto ‘Strengthening Global Health Architecture’ a delegation from GISAID attended the G20 Finance and Health Ministers meeting hosted by Indonesia, to discuss with G20 Member States’ and its partners their vision for GISAID+ (GISAID plus).
Global leaders reflected on the need to coordinate and strengthen resources during future pandemics. In particular Member States stressed the essential role GISAID plays in global health security, and discussed how global leaders could support GISAID’s expansion as a global resource to respond to other priority pathogens with major impact and pandemic-potential.
A peer-reviewed fact-finding and scoping study on digital sequence information on genetic resources in the context of the Convention on Biological Diversity and the Nagoya Protocol, highlights key advantages of GISAID’s sharing mechanism and a fair and equitable benefit-sharing resulting from access to data.
With the core principals of timely international sharing of health data for protecting populations against lethal infectious disease outbreaks and adherence to scientific etiquette of acknowledgement of the source of data has resulted in global trust and confidence in GISAID.
The GISAID Initiative involves public-private partnerships, among them the partnership with the Federal Republic of Germany, and governmental public-health and academic institutions in Argentina, Brazil, China, Republic of the Congo, Ethiopia, Indonesia, Malaysia, Russia, Senegal, Singapore, South Africa, and the support by Friends of GISAID, a registered non-profit association and administrative arm of the Initiative.
Congratulations to GISAID for ten years of successful work on pandemic influenza preparedness. As one of the key players in ensuring effective data sharing GISAID has made a significant contribution to global health security
Prof. Jane Halton AO PSM
Chair, Coalition for Epidemic Preparedness Innovations CEPI
Commemorating the centenary of the 1918 pandemic, the most catastrophic event in the recorded history of influenza, it is reassuring to know that GISAID is ready and prepared when a similar event emerges and threatens global health. Congratulations on bringing together one of the most successful global collaborations ever achieved
Prof. Dr Rob Webster
St Jude Children’s Research
Hospital, Memphis, Tennessee
The unique contribution of the GISAID data sharing mechanism is the confidence it has engendered among scientific and political communities as it has added to their capabilities to collaborate more effectively to combat influenza viruses
Dr med David Nabarro
United Nations System Coordinat.
for Avian & Human Influenza (ret)
We do need substantially innovative mechanisms for microbe sharing, if mankind is to survive future pandemics. GISAID is an excellent example!!!
Dr Suwit Wibulpolprasert
Ministry of Public Health, Thailand
International Health Policy Program Foundation
IFPMA acknowledges GISAID’s important role in providing the platform for the open and timely sharing of influenza data and building greater trust among countries and stakeholders, a key element to influenza global pandemic preparedness
Thomas B. Cueni
International Federation of Pharma
Manufacturers & Associations
The tenth anniversary of GISAID represents a landmark in global solidarity. A pandemic strain of influenza is perhaps the world's greatest threat. Everything GISAID stands for: virus sharing, cutting-edge research, open access, and international cooperation to guarantee health security couldn't be more important
Prof. Lawrence O. Gostin
WHO Collaborating Center on
National and Global Health Law
GISAID’s trustworthy data sharing principles forever transformed global collaboration in the fight against influenza, enabling unprecedented rapid response to outbreaks. In 2013, Nature called China’s sharing of H7N9 avian influenza data through GISAID ‘next to exemplary’
Prof. Dr George Fu Gao
Chinese Center for Disease Control and Prevention
A key to protecting the world from future viral threats is having immediate and open access to critical viral data. GISAID has established a highly effective, trusted and time-tested model for influenza data sharing that could serve as an important model for other viral families
GISAID successfully built upon the collaborative ethos of the 70-year old WHO Global Influenza Programme, to complement and extend the sharing of viruses, reagents & essential information
Dr med Wenqing Zhang
World Health Organization
Global Influenza Programme
The GISAID Initiative was established to champion (and enhance) rapid sequence data sharing for seasonal and pandemic influenza preparedness - a global public health imperative. GISAID’s success exceeded our expectations and provides an important model for rapid data sharing for other pathogens with pandemic potential
Not all big ideas become a reality and not all big ideas fill a global need. As a public-private partnership GISAID is a model for data sharing in the digital age. On its 10th anniversary we may look back at the initial inspiration and the headline of the supporting editorial in Nature that puts the point succinctly: Sharing saves lives
Dr med Bruce G. Gellin
Global Immunization, President
Sabin Vaccine Institute
ECDC congratulates GISAID for a successful 10 years of advocating for and implementing sharing of influenza sequence data. The initiative plays a key role in global and European pandemic preparedness and increases our understanding of the annual influenza seasons
Dr Mike Catchpole
European Centre for Disease
Prevention and Control (ECDC)
GISAID has advanced influenza virus data sharing to a new level, greatly contributing to the global effort to detect, respond, and mitigate seasonal and pandemic influenza
Prof. Dr med Peter Jay Hotez
Baylor College of Medicine, Dean
National School Tropical Medicine
Over the past decade, GISAID has been an invaluable global partner in fostering open access to data related to influenza, a central issue related to influenza and all EIDs
Prof. Dr med Keiji Fukuda
The University of Hong Kong
School of Public Health
GISAID encourages increased collection and rapid dissemination of data that improves our understanding of the complex and dynamic epidemiology of influenza viruses. On behalf of OFFLU network, we offer our congratulations on the contribution GISAID has made to build international collaboration over the last 10 years
Dr Peter Daniels
Dr David Swayne
OFFLU OIE/FAO Network of
Expertise on Animal Influenza
The pioneering concept of transparent data sharing developed GISAID into the premier source of influenza virus sequence information and proven its worth in outbreak situations
Prof. Dr Thomas C. Mettenleiter
Federal Research Institute
for Animal Health, Germany
Ten years after GISAID first introduced its game-changing mechanism, breaking data sharing barriers, it continues to be a most trusted leader in pandemic preparedness & response
Prof. Dr Yuelong Shu
Sun Yat-sen University, Dean
School of Public Health, Shenzhen
GISAID has become the most complete public database for influenza virus sequence data in support of fundamental science and public and animal health applications
Prof. Dr Ron Fouchier
Erasmus MC Rotterdam
Viroscience & Nat'l Influenza Cntr
By sharing influenza virus sequences among scientists around the world, GISAID has had a tremendous impact on influenza virus research
Prof. Dr Yoshihiro Kawaoka
University of Wisconsin-Madison
University of Tokyo
genome sequence submissions